L-Type Amino Acid Transporter 1-Utilizing Prodrugs of Ketoprofen Can Efficiently Reduce Brain Prostaglandin Levels

L-Type Amino Acid Transporter 1-Utilizing Prodrugs of Ketoprofen Can Efficiently Reduce Brain Prostaglandin Levels

In order to efficiently combat neuroinflammation, it is essential to deliver the anti-inflammatory drugs to their target sites in the brain. Pro-drugs utilizing the L-type amino acid transporter 1 (LAT1) can be transported across the blood-brain barrier (BBB) and the cellular barriers of the brain’s...

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Bibliographic Details
Main Authors: Ahmed Montaser, Marko Lehtonen, Mikko Gynther, Kristiina M. Huttunen
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Pharmaceutics
Subjects:
membrane transport
transporters
neuro-inflammation
LAT1-utilizing pro-drugs
prostaglandin E2
targeted brain delivery
Online Access:https://www.mdpi.com/1999-4923/12/4/344

Internet

https://www.mdpi.com/1999-4923/12/4/344

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