TMEM106B haplotypes have distinct gene expression patterns in aged brain

TMEM106B haplotypes have distinct gene expression patterns in aged brain

Abstract Background Single nucleotide polymorphisms (SNPs) inherited as one of two common haplotypes at the transmembrane protein 106B (TMEM106B) locus are associated with the risk of multiple neurodegenerative diseases, including frontotemporal lobar degeneration with pathological inclusions of TDP...

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Bibliographic Details
Main Authors: Yingxue Ren, Marka van Blitterswijk, Mariet Allen, Minerva M. Carrasquillo, Joseph S. Reddy, Xue Wang, Thomas G. Beach, Dennis W. Dickson, Nilüfer Ertekin-Taner, Yan W. Asmann, Rosa Rademakers
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Molecular Neurodegeneration
Subjects:
TMEM106B
Frontotemporal dementia, Co-expression networks, Differential expression
Synaptic transmission
Immune response
Progranulin
Online Access:http://link.springer.com/article/10.1186/s13024-018-0268-2

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http://link.springer.com/article/10.1186/s13024-018-0268-2

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