20(S)-Protopanaxadiol Inhibits Angiotensin II-Induced Epithelial- Mesenchymal Transition by Downregulating SIRT1

20(S)-Protopanaxadiol Inhibits Angiotensin II-Induced Epithelial- Mesenchymal Transition by Downregulating SIRT1

20(S)-Protopanaxadiol (PPD) is one of the major active metabolites in ginseng saponin. Our previous studies revealed a broad spectrum of antitumor effects of PPD. Angiotensin II (Ang II), the biologically active peptide of the renin-angiotensin system (RAS), plays a critical role in the metastasis o...

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Bibliographic Details
Main Authors: Yuchen Wang, Huali Xu, Wenwen Fu, Zeyuan Lu, Minyu Guo, Xueji Wu, Mingyang Sun, Yanzhe Liu, Xiaofeng Yu, Dayun Sui
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Pharmacology
Subjects:
20(S)-protopanaxadiol
angiotensin II
non-small cell lung cancer
epithelial-mesenchymal transition
SIRT1
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00475/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00475/full

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