HIV integration targeting: a pathway involving Transportin-3 and the nuclear pore protein RanBP2.

HIV integration targeting: a pathway involving Transportin-3 and the nuclear pore protein RanBP2.

Genome-wide siRNA screens have identified host cell factors important for efficient HIV infection, among which are nuclear pore proteins such as RanBP2/Nup358 and the karyopherin Transportin-3/TNPO3. Analysis of the roles of these proteins in the HIV replication cycle suggested that correct traffick...

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Bibliographic Details
Main Authors: Karen E Ocwieja, Troy L Brady, Keshet Ronen, Alyssa Huegel, Shoshannah L Roth, Torsten Schaller, Leo C James, Greg J Towers, John A T Young, Sumit K Chanda, Renate König, Nirav Malani, Charles C Berry, Frederic D Bushman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-03-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3053352?pdf=render

Internet

http://europepmc.org/articles/PMC3053352?pdf=render

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