Protocol for determining zinc-dependent β cell-selective small-molecule delivery in mouse pancreas
Summary: Targeted drug delivery to pancreatic islet β cells is an unmet clinical need. β cells possess a uniquely high Zn2+ concentration, and integrating Zn2+-binding activity into a small molecule can bias drug accumulation and activity toward β cells. This protocol can be used to evaluate a molec...
Main Authors: | , , |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2021-03-01
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Series: | STAR Protocols |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2666166720302501 |