Association of the hypoxia-inducible factor-1α (HIF-1α) gene polymorphisms with prognosis in ovarian clear cell carcinoma
Abstract Background Ovarian clear cell carcinoma (OCCC) is the second most common ovarian cancer after serous carcinoma in Japan. OCCC has a more unfavorable clinical outcome due to a poor response to platinum-based chemotherapy, compared with serous carcinoma. Hypoxia inducible factor-1α (HIF-1α) i...
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doaj-f258d5e0d7ec4a1791d8e6ee7fcb4b5e2020-11-25T01:15:44ZengBMCJournal of Ovarian Research1757-22152019-01-011211710.1186/s13048-019-0481-9Association of the hypoxia-inducible factor-1α (HIF-1α) gene polymorphisms with prognosis in ovarian clear cell carcinomaHiroyuki Suzuki0Mitsutake Yano1Mariko Miyazawa2Masaki Miyazawa3Naoki Ogane4Kosei Hasegawa5Hitoshi Tsuda6Masayuki Yoshida7Ryugo Okagaki8Osamu Ishihara9Masanori Yasuda10Department of Pathology, Saitama Medical University International Medical CenterDepartment of Pathology, Saitama Medical University International Medical CenterDepartment of Obstetrics and Gynecology, Tokai University School of MedicineDepartment of Obstetrics and Gynecology, Tokai University School of MedicineDivision of Pathology, Ashigarakami HospitalDepartment of Gynecologic Oncology, Saitama Medical University International Medical CenterDepartment of Basic Pathology, National Defense Medical CollegeDepartment of Pathology and Clinical Laboratories, National Cancer Center HospitalDepartment of Obstetrics and Gynecology, Saitama Medical University HospitalDepartment of Obstetrics and Gynecology, Saitama Medical University HospitalDepartment of Pathology, Saitama Medical University International Medical CenterAbstract Background Ovarian clear cell carcinoma (OCCC) is the second most common ovarian cancer after serous carcinoma in Japan. OCCC has a more unfavorable clinical outcome due to a poor response to platinum-based chemotherapy, compared with serous carcinoma. Hypoxia inducible factor-1α (HIF-1α) is a key regulator of cellular response to hypoxia and plays an important role in tumor growth, and HIF-1α gene single-nucleotide polymorphisms (SNPs) adversely affect the outcome in some cancers. Herein, we investigated the association of the HIF-1α gene SPNs with clinical outcome in OCCCs. Eighty-nine patients with OCCC were recruited in whom pathological diagnosis was confirmed with surgically resected specimen. Results The SNPs of C1772T and G1790A in the HIF-1α gene occurred in 23.6 and 3.3% of the patients, respectively. In the univariate analysis, overall survival was associated with stage and surgical residual tumor but not with the SNPs C1772T, G1790A, C1772T and/or G1790A. In the multivariate survival analysis, a significant association was observed between outcome and FIGO stage and/or surgical residual tumor; however, no association was obtained between HIF-1α gene SNPs and these factors. Conclusion In conclusion, unlike the other cancers in which HIF-1α gene SNPs were demonstrated to be associated with the outcome, OCCC prognosis may not be affected by HIF-1α gene SNPs. Further studies need to be performed to clarify the association of HIF-1α expression with the unfavorable prognosis in OCCCs, in terms of transcriptional/translational activity, nuclear translocation of the protein, and protein degradation.http://link.springer.com/article/10.1186/s13048-019-0481-9Ovarian clear cell carcinomaSingle-nucleotide polymorphisms (SNPs)Hypoxia-inducible factor-1α (HIF-1α)Prognosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hiroyuki Suzuki Mitsutake Yano Mariko Miyazawa Masaki Miyazawa Naoki Ogane Kosei Hasegawa Hitoshi Tsuda Masayuki Yoshida Ryugo Okagaki Osamu Ishihara Masanori Yasuda |
spellingShingle |
Hiroyuki Suzuki Mitsutake Yano Mariko Miyazawa Masaki Miyazawa Naoki Ogane Kosei Hasegawa Hitoshi Tsuda Masayuki Yoshida Ryugo Okagaki Osamu Ishihara Masanori Yasuda Association of the hypoxia-inducible factor-1α (HIF-1α) gene polymorphisms with prognosis in ovarian clear cell carcinoma Journal of Ovarian Research Ovarian clear cell carcinoma Single-nucleotide polymorphisms (SNPs) Hypoxia-inducible factor-1α (HIF-1α) Prognosis |
author_facet |
Hiroyuki Suzuki Mitsutake Yano Mariko Miyazawa Masaki Miyazawa Naoki Ogane Kosei Hasegawa Hitoshi Tsuda Masayuki Yoshida Ryugo Okagaki Osamu Ishihara Masanori Yasuda |
author_sort |
Hiroyuki Suzuki |
title |
Association of the hypoxia-inducible factor-1α (HIF-1α) gene polymorphisms with prognosis in ovarian clear cell carcinoma |
title_short |
Association of the hypoxia-inducible factor-1α (HIF-1α) gene polymorphisms with prognosis in ovarian clear cell carcinoma |
title_full |
Association of the hypoxia-inducible factor-1α (HIF-1α) gene polymorphisms with prognosis in ovarian clear cell carcinoma |
title_fullStr |
Association of the hypoxia-inducible factor-1α (HIF-1α) gene polymorphisms with prognosis in ovarian clear cell carcinoma |
title_full_unstemmed |
Association of the hypoxia-inducible factor-1α (HIF-1α) gene polymorphisms with prognosis in ovarian clear cell carcinoma |
title_sort |
association of the hypoxia-inducible factor-1α (hif-1α) gene polymorphisms with prognosis in ovarian clear cell carcinoma |
publisher |
BMC |
series |
Journal of Ovarian Research |
issn |
1757-2215 |
publishDate |
2019-01-01 |
description |
Abstract Background Ovarian clear cell carcinoma (OCCC) is the second most common ovarian cancer after serous carcinoma in Japan. OCCC has a more unfavorable clinical outcome due to a poor response to platinum-based chemotherapy, compared with serous carcinoma. Hypoxia inducible factor-1α (HIF-1α) is a key regulator of cellular response to hypoxia and plays an important role in tumor growth, and HIF-1α gene single-nucleotide polymorphisms (SNPs) adversely affect the outcome in some cancers. Herein, we investigated the association of the HIF-1α gene SPNs with clinical outcome in OCCCs. Eighty-nine patients with OCCC were recruited in whom pathological diagnosis was confirmed with surgically resected specimen. Results The SNPs of C1772T and G1790A in the HIF-1α gene occurred in 23.6 and 3.3% of the patients, respectively. In the univariate analysis, overall survival was associated with stage and surgical residual tumor but not with the SNPs C1772T, G1790A, C1772T and/or G1790A. In the multivariate survival analysis, a significant association was observed between outcome and FIGO stage and/or surgical residual tumor; however, no association was obtained between HIF-1α gene SNPs and these factors. Conclusion In conclusion, unlike the other cancers in which HIF-1α gene SNPs were demonstrated to be associated with the outcome, OCCC prognosis may not be affected by HIF-1α gene SNPs. Further studies need to be performed to clarify the association of HIF-1α expression with the unfavorable prognosis in OCCCs, in terms of transcriptional/translational activity, nuclear translocation of the protein, and protein degradation. |
topic |
Ovarian clear cell carcinoma Single-nucleotide polymorphisms (SNPs) Hypoxia-inducible factor-1α (HIF-1α) Prognosis |
url |
http://link.springer.com/article/10.1186/s13048-019-0481-9 |
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