In vivo characterization of the activities of novel cyclodipeptide oxidases: new tools for increasing chemical diversity of bioproduced 2,5-diketopiperazines in Escherichia coli

In vivo characterization of the activities of novel cyclodipeptide oxidases: new tools for increasing chemical diversity of bioproduced 2,5-diketopiperazines in Escherichia coli

Abstract Background Cyclodipeptide oxidases (CDOs) are enzymes involved in the biosynthesis of 2,5-diketopiperazines, a class of naturally occurring compounds with a large range of pharmaceutical activities. CDOs belong to cyclodipeptide synthase (CDPS)-dependent pathways, in which they play an earl...

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Bibliographic Details
Main Authors: Fabien Le Chevalier, Isabelle Correia, Lucrèce Matheron, Morgan Babin, Mireille Moutiez, Nicolas Canu, Muriel Gondry, Olivier Lequin, Pascal Belin
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Microbial Cell Factories
Subjects:
Synthetic biology
Combinatorial biosynthesis
Natural products
2,5-diketopiperazine
Cyclodipeptide synthase
Cyclodipeptide oxidase
Online Access:http://link.springer.com/article/10.1186/s12934-020-01432-y

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http://link.springer.com/article/10.1186/s12934-020-01432-y

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