Tolerogenic Transcriptional Signatures of Steady-State and Pathogen-Induced Dendritic Cells

Tolerogenic Transcriptional Signatures of Steady-State and Pathogen-Induced Dendritic Cells

Dendritic cells (DCs) are key directors of tolerogenic and immunogenic immune responses. During the steady state, DCs maintain T cell tolerance to self-antigens by multiple mechanisms including inducing anergy, deletion, and Treg activity. All of these mechanisms help to prevent autoimmune diseases...

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Bibliographic Details
Main Authors: Emilia Vendelova, Diyaaeldin Ashour, Patrick Blank, Florian Erhard, Antoine-Emmanuel Saliba, Ulrich Kalinke, Manfred B. Lutz
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Immunology
Subjects:
tolerogenic dendritic cells
transcriptional profiling
steady-state dendritic cells
bacteria
mycobacteria
helminths
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00333/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00333/full

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