Makorin 1 controls embryonic patterning by alleviating Bruno1-mediated repression of oskar translation.

Makorin 1 controls embryonic patterning by alleviating Bruno1-mediated repression of oskar translation.

Makorins are evolutionary conserved proteins that contain C3H-type zinc finger modules and a RING E3 ubiquitin ligase domain. In Drosophila, maternal Makorin 1 (Mkrn1) has been linked to embryonic patterning but the mechanism remained unsolved. Here, we show that Mkrn1 is essential for axis specific...

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Bibliographic Details
Main Authors: Annabelle Dold, Hong Han, Niankun Liu, Andrea Hildebrandt, Mirko Brüggemann, Cornelia Rücklé, Heike Hänel, Anke Busch, Petra Beli, Kathi Zarnack, Julian König, Jean-Yves Roignant, Paul Lasko
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1008581

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https://doi.org/10.1371/journal.pgen.1008581

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