Enrichment of plasma extracellular vesicles for reliable quantification of their size and concentration for biomarker discovery

Abstract Human plasma is a complex fluid, increasingly used for extracellular vesicle (EV) biomarker studies. Our aim was to find a simple EV-enrichment method for reliable quantification of EVs in plasma to be used as biomarker of disease. Plasma of ten healthy subjects was processed using sediment...

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Bibliographic Details
Main Authors: Marija Holcar, Jana Ferdin, Simona Sitar, Magda Tušek-Žnidarič, Vita Dolžan, Ana Plemenitaš, Ema Žagar, Metka Lenassi
Format: Article
Language:English
Published: Nature Publishing Group 2020-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-78422-y