QSAR, Molecular Docking and protein ligand interaction fingerprint studies of N-phenyl dichloroacetamide derivatives as anticancer agents

<p>Dichloroacetate (DCA) is a pyruvate mimetic compound that stimulates the activity of the enzyme pyruvate dehydrogenase (PDH) through inhibition of the enzyme pyruvate dehydrogenase kinases (PDK1-4). DCA works by turning on the apoptosis which is suppressed in tumor cells, hence let them to...

Full description

Bibliographic Details
Main Authors: Masood Fereidoonnezhad, Zeinab Faghih, Elham Jokar, Ayyub Mojaddami, Zahra Rezaei, Mehdi Khoshneviszadeh
Format: Article
Language:English
Published: Shiraz University of Medical Sciences 2016-06-01
Series:Trends in Pharmaceutical Sciences
Subjects:
Online Access:http://tips.sums.ac.ir/index.php/TiPS/article/view/75