QSAR, Molecular Docking and protein ligand interaction fingerprint studies of N-phenyl dichloroacetamide derivatives as anticancer agents
<p>Dichloroacetate (DCA) is a pyruvate mimetic compound that stimulates the activity of the enzyme pyruvate dehydrogenase (PDH) through inhibition of the enzyme pyruvate dehydrogenase kinases (PDK1-4). DCA works by turning on the apoptosis which is suppressed in tumor cells, hence let them to...
Main Authors: | , , , , , |
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Format: | Article |
Language: | English |
Published: |
Shiraz University of Medical Sciences
2016-06-01
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Series: | Trends in Pharmaceutical Sciences |
Subjects: | |
Online Access: | http://tips.sums.ac.ir/index.php/TiPS/article/view/75 |
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