Mitochondrial Dysfunction and Oxidative Stress Promote Apoptotic Cell Death in the Striatum via Cytochrome c/ Caspase-3 Signaling Cascade Following Chronic Rotenone Intoxication in Rats

Mitochondrial Dysfunction and Oxidative Stress Promote Apoptotic Cell Death in the Striatum via Cytochrome c/ Caspase-3 Signaling Cascade Following Chronic Rotenone Intoxication in Rats

Parkinson’s disease (PD) is a progressive neurological disorder marked by nigrostriatal dopaminergic degeneration. Evidence suggests that mitochondrial dysfunction may be linked to PD through a variety of different pathways, including free-radical generation and dysfunction of the mitochondrial Comp...

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Bibliographic Details
Main Authors: Chia-Wei Liou, Chi-Ren Huang, Yao-Chung Chuang, Shang-Der Chen, Ching-Hsiao Cheng, Tsu-Kung Lin
Format: Article
Language:English
Published: MDPI AG 2012-07-01
Series:International Journal of Molecular Sciences
Subjects:
rotenone
Parkinson’s disease
mitochondria
complex I
apoptotic cell death
striatum
Online Access:http://www.mdpi.com/1422-0067/13/7/8722

Internet

http://www.mdpi.com/1422-0067/13/7/8722

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