Influence of Indoleamine-2,3-Dioxygenase and Its Metabolite Kynurenine on γδ T Cell Cytotoxicity against Ductal Pancreatic Adenocarcinoma Cells

Influence of Indoleamine-2,3-Dioxygenase and Its Metabolite Kynurenine on γδ T Cell Cytotoxicity against Ductal Pancreatic Adenocarcinoma Cells

Background: Pancreatic ductal adenocarcinoma (PDAC) is a malignant gastrointestinal disease. The enzyme indoleamine-2,3-dioxgenase (IDO) is often overexpressed in PDAC and its downstream metabolite kynurenine has been reported to inhibit T cell activation and proliferation. Since γδ T cells are of h...

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Bibliographic Details
Main Authors: Hannah Jonescheit, Hans-Heinrich Oberg, Daniel Gonnermann, Martin Hermes, Vjola Sulaj, Christian Peters, Dieter Kabelitz, Daniela Wesch
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Cells
Subjects:
gamma delta T cells
ductal pancreatic adenocarcinoma
indoleamine-2,3-dioxygenase
kynurenine
cytotoxicity
bispecific antibody
Online Access:https://www.mdpi.com/2073-4409/9/5/1140

Internet

https://www.mdpi.com/2073-4409/9/5/1140

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