Tuned polymerization of the transcription factor Yan limits off-DNA sequestration to confer context-specific repression

Tuned polymerization of the transcription factor Yan limits off-DNA sequestration to confer context-specific repression

During development, transcriptional complexes at enhancers regulate gene expression in complex spatiotemporal patterns. To achieve robust expression without spurious activation, the affinity and specificity of transcription factor–DNA interactions must be precisely balanced. Protein–protein interact...

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Bibliographic Details
Main Authors: C Matthew Hope, Jemma L Webber, Sherzod A Tokamov, Ilaria Rebay
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-11-01
Series:eLife
Subjects:
ETS repressor
photoreceptor
eye development
mathematical modeling
receptor tyrosine kinase signaling
Online Access:https://elifesciences.org/articles/37545

Internet

https://elifesciences.org/articles/37545

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