Dipotassium Glycyrrhizate Improves Intestinal Mucosal Healing by Modulating Extracellular Matrix Remodeling Genes and Restoring Epithelial Barrier Functions

Dipotassium Glycyrrhizate Improves Intestinal Mucosal Healing by Modulating Extracellular Matrix Remodeling Genes and Restoring Epithelial Barrier Functions

Gut mucosal healing (MH) is considered a key therapeutic target and prognostic parameter in the management of inflammatory bowel disease (IBD). The dipotassium glycyrrhizate (DPG), a salt of the glycoconjugated triterpene glycyrrhizin, has been shown to inhibit the High Mobility Group Box 1 (HMGB1)...

Full description

Bibliographic Details
Main Authors: Laura Stronati, Francesca Palone, Anna Negroni, Eleonora Colantoni, Anna Barbara Mancuso, Salvatore Cucchiara, Vincenzo Cesi, Sara Isoldi, Roberta Vitali
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Immunology
Subjects:
dipotassium glycyrrhizate
mucosal healing
DSS-induced colitis
plaur
VTN
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00939/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00939/full

Similar Items