Critical role of TLR4 in human metapneumovirus mediated innate immune responses and disease pathogenesis.

Human metapneumovirus (hMPV) is one of the main causes of acute respiratory tract infections in children, elderly and immunocompromised patients. The mammalian Toll-like receptors (TLR) were identified as critical regulators of innate immunity to a variety of microbes, including viruses. We have rec...

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Bibliographic Details
Main Authors: Thangam Sudha Velayutham, Deepthi Kolli, Teodora Ivanciuc, Roberto P Garofalo, Antonella Casola
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3812158?pdf=render