Mycobacterium tuberculosis SufR responds to nitric oxide via its 4Fe–4S cluster and regulates Fe–S cluster biogenesis for persistence in mice

Mycobacterium tuberculosis SufR responds to nitric oxide via its 4Fe–4S cluster and regulates Fe–S cluster biogenesis for persistence in mice

The persistence of Mycobacterium tuberculosis (Mtb) is a major problem in managing tuberculosis (TB). Host-generated nitric oxide (NO) is perceived as one of the signals by Mtb to reprogram metabolism and respiration for persistence. However, the mechanisms involved in NO sensing and reorganizing Mt...

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Bibliographic Details
Main Authors: Kushi Anand, Ashutosh Tripathi, Kaustubh Shukla, Nitish Malhotra, Anil Kumar Jamithireddy, Rajiv Kumar Jha, Susmit Narayan Chaudhury, Raju S. Rajmani, Arati Ramesh, Valakunja Nagaraja, Balasubramanian Gopal, Ganesh Nagaraju, Aswin Sai Narain Seshayee, Amit Singh
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:Redox Biology
Subjects:
Dinitrosyl-iron-dithiol complex
Spare respiratory capacity
Redox potential
Gene regulation
Inducible nitric oxide synthase
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231721002214

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