The passage from bone marrow niche to bloodstream triggers the metabolic impairment in Fanconi Anemia mononuclear cells

The passage from bone marrow niche to bloodstream triggers the metabolic impairment in Fanconi Anemia mononuclear cells

Fanconi Anemia (FA) is a disease characterized by bone marrow (BM) failure and aplastic anemia. In addition to a defective DNA repair system, other mechanisms are involved in its pathogenesis, such as defective mitochondrial metabolism, accumulation of lipids, and increment of oxidative stress produ...

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Bibliographic Details
Main Authors: Enrico Cappelli, Paolo Degan, Silvia Bruno, Filomena Pierri, Maurizio Miano, Federica Raggi, Piero Farruggia, Cristina Mecucci, Barbara Crescenzi, Valeria Naim, Carlo Dufour, Silvia Ravera
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Redox Biology
Subjects:
Aerobic metabolism
Antioxidant defenses
Bone marrow aplasia
Hypoxic and normoxic conditions
Mitochondria
Oxidative stress production
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231720308235

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http://www.sciencedirect.com/science/article/pii/S2213231720308235

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