How do researchers determine the difference to be detected in superiority trials? Results of a survey from a panel of researchers

How do researchers determine the difference to be detected in superiority trials? Results of a survey from a panel of researchers

Abstract Background There is currently no guidance for selecting a specific difference to be detected in a superiority trial. We explored 3 factors that in our opinion should influence the difference to be detected (type of outcome, patient age group, and presence of treatment side-effects), and 3 t...

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Bibliographic Details
Main Authors: Angèle Gayet-Ageron, Anne-Sophie Jannot, Thomas Agoritsas, Sandrine Rudaz, Christophe Combescure, Thomas Perneger
Format: Article
Language:English
Published: BMC 2016-07-01
Series:BMC Medical Research Methodology
Subjects:
Superiority trial
Randomized controlled trials
Difference to be detected
Minimal clinically important difference
Odds ratio
Primary outcome
Online Access:http://link.springer.com/article/10.1186/s12874-016-0195-2

Internet

http://link.springer.com/article/10.1186/s12874-016-0195-2

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