The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytes

The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytes

In the brain, astrocytes represent the cellular population that expresses the highest amount of connexins (Cxs). This family of membrane proteins is the molecular constituent of gap junction channels and hemichannels that provide pathways for direct cytoplasm-to-cytoplasm and inside-out exchange, re...

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Bibliographic Details
Main Authors: Veronica eAbudara, John eBechberger, Moises eFreitas-Andrade, Marijke eDe Bock, Nan eWang, Geert eBultynck, Christian eNaus, Luc eLeybaert, Christian eGiaume
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-10-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Connexins
Gap Junctions
glial cells
astroglia
Mimetic peptide
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00306/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00306/full

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