Mitochondrial fatty acid synthesis coordinates oxidative metabolism in mammalian mitochondria

Mitochondrial fatty acid synthesis coordinates oxidative metabolism in mammalian mitochondria

Cells harbor two systems for fatty acid synthesis, one in the cytoplasm (catalyzed by fatty acid synthase, FASN) and one in the mitochondria (mtFAS). In contrast to FASN, mtFAS is poorly characterized, especially in higher eukaryotes, with the major product(s), metabolic roles, and cellular function...

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Bibliographic Details
Main Authors: Sara M Nowinski, Ashley Solmonson, Scott F Rusin, J Alan Maschek, Claire L Bensard, Sarah Fogarty, Mi-Young Jeong, Sandra Lettlova, Jordan A Berg, Jeffrey T Morgan, Yeyun Ouyang, Bradley C Naylor, Joao A Paulo, Katsuhiko Funai, James E Cox, Steven P Gygi, Dennis R Winge, Ralph J DeBerardinis, Jared Rutter
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-08-01
Series:eLife
Subjects:
mitochondria
fatty acid synthesis
metabolism
electron transport chain
myoblast
TCA cycle
Online Access:https://elifesciences.org/articles/58041

Internet

https://elifesciences.org/articles/58041

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