Generation of integration-free induced pluripotent stem cells from a patient with spina bifida

A skin biopsy was obtained from a 14-year-old female patient with a history of Myelomeningocele. Dermal fibroblasts were isolated and reprogrammed with Sendai virus (SeV) vectors encoding OCT3/4, SOX2, KLF4, and c-MYC. The generated induced Pluripotent Stem Cell (iPSC) clones NTDi4_09A were free of...

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Bibliographic Details
Main Authors: Hongran Wang, Shuying Zhao, Richard H. Finnell, Timothy George, Austin J. Cooney
Format: Article
Language:English
Published: Elsevier 2018-08-01
Series:Stem Cell Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506118301259