The ATR-Activation Domain of TopBP1 Is Required for the Suppression of Origin Firing during the S Phase

The ATR-Activation Domain of TopBP1 Is Required for the Suppression of Origin Firing during the S Phase

The mammalian DNA replication program is controlled at two phases, the licensing of potential origins of DNA replication in early gap 1 (G1), and the selective firing of a subset of licenced origins in the synthesis (S) phase. Upon entry into the S phase, serine/threonine-protein kinase ATR (ATR) is...

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Bibliographic Details
Main Authors: Miiko Sokka, Dennis Koalick, Peter Hemmerich, Juhani E. Syväoja, Helmut Pospiech
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:International Journal of Molecular Sciences
Subjects:
DNA replication
S phase
origin firing
TopBP1
ATR
DNA fiber assay
Online Access:http://www.mdpi.com/1422-0067/19/8/2376

Internet

http://www.mdpi.com/1422-0067/19/8/2376

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