Ictal but not interictal epileptic discharges activate astrocyte endfeet and elicit cerebral arteriole responses.

Ictal but not interictal epileptic discharges activate astrocyte endfeet and elicit cerebral arteriole responses.

Activation of astrocytes by neuronal signals plays a central role in the control of neuronal activity-dependent blood flow changes in the normal brain. The cellular pathways that mediate neurovascular coupling in the epileptic brain remain, however, poorly defined. In a cortical slice model of epile...

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Bibliographic Details
Main Authors: Marta eGomez-Gonzalo, Gabriele eLosi, Marco eBrondi, Laura eUva, Sebastian eSulis-Sato, Marco eDe Curtis, Gian Michele eRatto, Giorgio eCarmignoto
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-06-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Calcium
Epilepsy
neurovascular coupling
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2011.00008/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2011.00008/full

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