Restoration of visual function in advanced disease after transplantation of purified human pluripotent stem cell-derived cone photoreceptors

Restoration of visual function in advanced disease after transplantation of purified human pluripotent stem cell-derived cone photoreceptors

Summary: Age-related macular degeneration and other macular diseases result in the loss of light-sensing cone photoreceptors, causing irreversible sight impairment. Photoreceptor replacement may restore vision by transplanting healthy cells, which must form new synaptic connections with the recipien...

Full description

Bibliographic Details
Main Authors: Joana Ribeiro, Christopher A. Procyk, Emma L. West, Michelle O’Hara-Wright, Monica F. Martins, Majid Moshtagh Khorasani, Aura Hare, Mark Basche, Milan Fernando, Debbie Goh, Neeraj Jumbo, Matteo Rizzi, Kate Powell, Menahil Tariq, Michel Michaelides, James W.B. Bainbridge, Alexander J. Smith, Rachael A. Pearson, Anai Gonzalez-Cordero, Robin R. Ali
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Cell Reports
Subjects:
retinal organoid
transplantation
cell therapy
cone photoreceptor
outer segment
rescue
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721003363

Internet

http://www.sciencedirect.com/science/article/pii/S2211124721003363

Similar Items