Identification of Rare PB2-D701N Mutation from a Patient with Severe Influenza: Contribution of the PB2-D701N Mutation to the Pathogenicity of Human Influenza

Identification of Rare PB2-D701N Mutation from a Patient with Severe Influenza: Contribution of the PB2-D701N Mutation to the Pathogenicity of Human Influenza

Several amino acid changes have been previously implicated in adaptation of avian influenza viruses to human hosts, among them the D701N change in the PB2 polymerase subunit that also is the main determinant of avian virus pathogenesis in animal models. However, previous studies using recombinant vi...

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Bibliographic Details
Main Authors: Amelia Nieto, Francisco Pozo, Matxalen Vidal-García, Manuel Omeñaca, Inmaculada Casas, Ana Falcón
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-04-01
Series:Frontiers in Microbiology
Subjects:
influenza virus
pathogenicity
PB2 subunit
D701N mutation
adaptation of avian viruses
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2017.00575/full

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http://journal.frontiersin.org/article/10.3389/fmicb.2017.00575/full

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