Perforin evolved from a gene duplication of MPEG1, followed by a complex pattern of gene gain and loss within <it>Euteleostomi</it>
<p>Abstract</p> <p>Background</p> <p>The pore-forming protein perforin is central to the granule-exocytosis pathway used by cytotoxic lymphocytes to kill abnormal cells. Although this mechanism of killing is conserved in bony vertebrates, cytotoxic cells are present in...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2012-05-01
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| Series: | BMC Evolutionary Biology |
| Online Access: | http://www.biomedcentral.com/1471-2148/12/59 |