Efficient reduction of synthetic mRNA induced immune activation by simultaneous delivery of B18R encoding mRNA

Efficient reduction of synthetic mRNA induced immune activation by simultaneous delivery of B18R encoding mRNA

Abstract The application of synthetic modified messenger RNA (mRNA) is a promising approach for the treatment of a variety of diseases and vaccination. In the past few years, different modifications of synthetic mRNA were applied to render the mRNA more stable and less immunogenic. However, the repe...

Full description

Bibliographic Details
Main Authors: Tatjana Michel, Sonia Golombek, Heidrun Steinle, Ludmilla Hann, Ana Velic, Boris Macek, Stefanie Krajewski, Christian Schlensak, Hans Peter Wendel, Meltem Avci-Adali
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Journal of Biological Engineering
Subjects:
Immune response
B18R
Modified mRNA
Type I IFN
Online Access:http://link.springer.com/article/10.1186/s13036-019-0172-5

Internet

http://link.springer.com/article/10.1186/s13036-019-0172-5

Similar Items