Prolonged bioluminescence monitoring in mouse ex vivo bone culture revealed persistent circadian rhythms in articular cartilages and growth plates.

Prolonged bioluminescence monitoring in mouse ex vivo bone culture revealed persistent circadian rhythms in articular cartilages and growth plates.

The bone is a metabolically active organ which undergoes repeated remodeling cycles of bone resorption and formation. In this study, we revealed a robust and extremely long-lasting circadian rhythm in ex vivo culture maintained for over six months from the femoral bone of a PERIOD2(Luciferase) mouse...

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Bibliographic Details
Main Authors: Naoki Okubo, Yoichi Minami, Hiroyoshi Fujiwara, Yasuhiro Umemura, Yoshiki Tsuchiya, Toshiharu Shirai, Ryo Oda, Hitoshi Inokawa, Toshikazu Kubo, Kazuhiro Yagita
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3817244?pdf=render

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http://europepmc.org/articles/PMC3817244?pdf=render

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