Programmable mutually exclusive alternative splicing for generating RNA and protein diversity

Alternative splicing expands the genetic coding capacity and proteomic diversity of the cell. Here the authors create a synthetic biology platform for regulating four programmable exons in modular transcription factors.

Bibliographic Details
Main Authors: Melina Mathur, Cameron M. Kim, Sarah A. Munro, Shireen S. Rudina, Eric M. Sawyer, Christina D. Smolke
Format: Article
Language:English
Published: Nature Publishing Group 2019-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-10403-w