Programmable mutually exclusive alternative splicing for generating RNA and protein diversity

Alternative splicing expands the genetic coding capacity and proteomic diversity of the cell. Here the authors create a synthetic biology platform for regulating four programmable exons in modular transcription factors.

Bibliographic Details
Main Authors:	Melina Mathur, Cameron M. Kim, Sarah A. Munro, Shireen S. Rudina, Eric M. Sawyer, Christina D. Smolke
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-06-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-10403-w

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spelling	doaj-f2ae05290582465fb58220b0ccf48cb82021-05-11T12:15:07ZengNature Publishing GroupNature Communications2041-17232019-06-0110111310.1038/s41467-019-10403-wProgrammable mutually exclusive alternative splicing for generating RNA and protein diversityMelina Mathur0Cameron M. Kim1Sarah A. Munro2Shireen S. Rudina3Eric M. Sawyer4Christina D. Smolke5Department of Bioengineering, Stanford UniversityDepartment of Bioengineering, Stanford UniversityDepartment of Bioengineering, Stanford UniversityDepartment of Bioengineering, Stanford UniversityDepartment of Bioengineering, Stanford UniversityDepartment of Bioengineering, Stanford UniversityAlternative splicing expands the genetic coding capacity and proteomic diversity of the cell. Here the authors create a synthetic biology platform for regulating four programmable exons in modular transcription factors.https://doi.org/10.1038/s41467-019-10403-w
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Melina Mathur Cameron M. Kim Sarah A. Munro Shireen S. Rudina Eric M. Sawyer Christina D. Smolke
spellingShingle	Melina Mathur Cameron M. Kim Sarah A. Munro Shireen S. Rudina Eric M. Sawyer Christina D. Smolke Programmable mutually exclusive alternative splicing for generating RNA and protein diversity Nature Communications
author_facet	Melina Mathur Cameron M. Kim Sarah A. Munro Shireen S. Rudina Eric M. Sawyer Christina D. Smolke
author_sort	Melina Mathur
title	Programmable mutually exclusive alternative splicing for generating RNA and protein diversity
title_short	Programmable mutually exclusive alternative splicing for generating RNA and protein diversity
title_full	Programmable mutually exclusive alternative splicing for generating RNA and protein diversity
title_fullStr	Programmable mutually exclusive alternative splicing for generating RNA and protein diversity
title_full_unstemmed	Programmable mutually exclusive alternative splicing for generating RNA and protein diversity
title_sort	programmable mutually exclusive alternative splicing for generating rna and protein diversity
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-06-01
description	Alternative splicing expands the genetic coding capacity and proteomic diversity of the cell. Here the authors create a synthetic biology platform for regulating four programmable exons in modular transcription factors.
url	https://doi.org/10.1038/s41467-019-10403-w
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Programmable mutually exclusive alternative splicing for generating RNA and protein diversity

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