Features of the Chaperone Cellular Network Revealed through Systematic Interaction Mapping

Features of the Chaperone Cellular Network Revealed through Systematic Interaction Mapping

A comprehensive view of molecular chaperone function in the cell was obtained through a systematic global integrative network approach based on physical (protein-protein) and genetic (gene-gene or epistatic) interaction mapping. This allowed us to decipher interactions involving all core chaperones...

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Bibliographic Details
Main Authors: Kamran Rizzolo, Jennifer Huen, Ashwani Kumar, Sadhna Phanse, James Vlasblom, Yoshito Kakihara, Hussein A. Zeineddine, Zoran Minic, Jamie Snider, Wen Wang, Carles Pons, Thiago V. Seraphim, Edgar Erik Boczek, Simon Alberti, Michael Costanzo, Chad L. Myers, Igor Stagljar, Charles Boone, Mohan Babu, Walid A. Houry
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Cell Reports
Subjects:
chaperone network
genetic interactions
genetic interaction profiles
physical interactions
Hsp90
NAJ chaperone complex
R2TP
Rvb1
Rvb2
perinuclear condensate
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717312160

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http://www.sciencedirect.com/science/article/pii/S2211124717312160

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