A New alpha5beta1 integrin-dependent survival pathway through GSK3beta activation in leukemic cells.
Cell survival mediated by integrin engagement has been implicated in cell adhesion-mediated drug resistance. We have recently demonstrated that the activation of glycogen synthase kinase 3 beta (GSK3beta) is a new pathway supporting the chemoresistance of leukemic cells adhered to fibronectin.We sho...
Main Authors: | , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2010-03-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC2843713?pdf=render |