Plasma 24S-hydroxycholesterol (cerebrosterol) is increased in Alzheimer and vascular demented patients

Plasma 24S-hydroxycholesterol (cerebrosterol) is increased in Alzheimer and vascular demented patients

Alzheimer's disease (AD) is characterized by the presence of senile plaques, neurofibrillary tangles, and neuronal cell loss associated with membrane cholesterol release. 24S-hydroxycholesterol (24S-OH-Chol) is an enzymatically oxidized product of cholesterol mainly synthesized in the brain. We...

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Bibliographic Details
Main Authors: Dieter Lütjohann, Andreas Papassotiropoulos, Ingemar Björkhem, Sandra Locatelli, Metin Bagli, Randi D. Oehring, Uwe Schlegel, Frank Jessen, Marie Luise Rao, Klaus von Bergmann, Reinhard Heun
Format: Article
Language:English
Published: Elsevier 2000-02-01
Series:Journal of Lipid Research
Subjects:
brain cholesterol
apolipoprotein E
cell membrane
isotope dilution–mass spectrometry
hippocampus
senile plaques
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520320526

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http://www.sciencedirect.com/science/article/pii/S0022227520320526

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