A Candidate Regulatory Variant at the TREM Gene Cluster Confer Alzheimer’s Disease Risk by Modulating Both Amyloid-β Pathology and Neuronal Degeneration

A Candidate Regulatory Variant at the TREM Gene Cluster Confer Alzheimer’s Disease Risk by Modulating Both Amyloid-β Pathology and Neuronal Degeneration

Background: rs9357347 located at the triggering receptor expressed on myeloid cells (TREM) gene cluster could increase TREM2 and TREM-like transcript 1 (TREML1) brain gene expression, which is considered to play a protective role against Alzheimer’s disease (AD).Objectives: To investigate the role o...

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Bibliographic Details
Main Authors: Mei-Ling Tian, Xiao-Neng Ni, Jie-Qiong Li, Chen-Chen Tan, Xi-Peng Cao, Lan Tan, for the Alzheimer’s Disease Neuroimaging Initiative
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Neuroscience
Subjects:
Alzheimer’s disease
TREM2 gene
TREML1
rs9357347
genetic mechanism
cerebrospinal fluid
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.00742/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2019.00742/full

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