Time-course global proteome analyses reveal an inverse correlation between Aβ burden and immunoglobulin M levels in the APPNL-F mouse model of Alzheimer disease.

Time-course global proteome analyses reveal an inverse correlation between Aβ burden and immunoglobulin M levels in the APPNL-F mouse model of Alzheimer disease.

Alzheimer disease (AD) stands out amongst highly prevalent diseases because there is no effective treatment nor can the disease be reliably diagnosed at an early stage. A hallmark of AD is the accumulation of aggregation-prone amyloid β peptides (Aβ), the main constituent of amyloid plaques. To iden...

Full description

Bibliographic Details
Main Authors: Hansen Wang, Declan Williams, Jennifer Griffin, Takashi Saito, Takaomi C Saido, Paul E Fraser, Ekaterina Rogaeva, Gerold Schmitt-Ulms
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5568403?pdf=render

Internet

http://europepmc.org/articles/PMC5568403?pdf=render

Similar Items