Gab1 and Mapk Signaling Are Essential in the Hair Cycle and Hair Follicle Stem Cell Quiescence

Gab1 and Mapk Signaling Are Essential in the Hair Cycle and Hair Follicle Stem Cell Quiescence

Gab1 is a scaffold protein that acts downstream of receptor tyrosine kinases. Here, we produced conditional Gab1 mutant mice (by K14- and Krox20-cre) and show that Gab1 mediates crucial signals in the control of both the hair cycle and the self-renewal of hair follicle stem cells. Remarkably, mutant...

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Bibliographic Details
Main Authors: Özlem Akilli Öztürk, Hubert Pakula, Jolanta Chmielowiec, Jingjing Qi, Simone Stein, Linxiang Lan, Yoshiteru Sasaki, Klaus Rajewsky, Walter Birchmeier
Format: Article
Language:English
Published: Elsevier 2015-10-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715010268

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http://www.sciencedirect.com/science/article/pii/S2211124715010268

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