Automated spatial brain normalization and hindbrain white matter reference tissue give improved [18F]-florbetaben PET quantitation in Alzheimer´s model mice

Automated spatial brain normalization and hindbrain white matter reference tissue give improved [18F]-florbetaben PET quantitation in Alzheimer´s model mice

Preclinical PET studies of β-amyloid (Aβ) accumulation are of growing importance, but comparisons between research sites require standardized and optimized methods for quantitation. Therefore we aimed to evaluate systematically the 1) impact of an automated algorithm for spatial brain normalization,...

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Bibliographic Details
Main Authors: Felix eOverhoff, Matthias eBrendel, Anna eJaworska, Viktoria eKorzhova, Andreas eDelker, Federico eProbst, Carola eFocke, Franz-Josef eGildehaus, Janette eCarlsen, Karlheinz eBaumann, Christian eHaass, Peter eBartenstein, Jochen eHerms, Axel eRominger
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-02-01
Series:Frontiers in Neuroscience
Subjects:
Alzheimer's disease
beta-amyloid
brain normalization
Small animal PET
reference region
[18F]florbetaben
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnins.2016.00045/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnins.2016.00045/full

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