Transcriptomic Features of T Cell-Barren Tumors Are Conserved Across Diverse Tumor Types

Transcriptomic Features of T Cell-Barren Tumors Are Conserved Across Diverse Tumor Types

Background: Understanding how tumors subvert immune destruction is essential to the development of cancer immunotherapies. New evidence suggests that tumors limit anti-tumor immunity by exploiting transcriptional programs that regulate intratumoral trafficking and accumulation of effector cells. Her...

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Bibliographic Details
Main Authors: Eric D. Routh, Ashok K. Pullikuth, Guangxu Jin, Julia Chifman, Jeff W. Chou, Ralph B. D'Agostino, Ken-ichiro Seino, Haruka Wada, Cristin G. Print, Wei Zhang, Yong Lu, Lance D. Miller
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Immunology
Subjects:
tumor biology
immune evasion
tumor-infiltrating T cells
transcriptomics
bioinformatics
bone morphogenetic protein 7 (BMP7)
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00057/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00057/full

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