Y1 and Y5 receptors are both required for the regulation of food intake and energy homeostasis in mice.

Y1 and Y5 receptors are both required for the regulation of food intake and energy homeostasis in mice.

Neuropeptide Y (NPY) acting in the hypothalamus is one of the most powerful orexigenic agents known. Of the five known Y receptors, hypothalamic Y1 and Y5 have been most strongly implicated in mediating hyperphagic effects. However, knockout of individual Y1 or Y5 receptors induces late-onset obesit...

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Bibliographic Details
Main Authors: Amy D Nguyen, Natalie F Mitchell, Shu Lin, Laurence Macia, Ernie Yulyaningsih, Paul A Baldock, Ronaldo F Enriquez, Lei Zhang, Yan-Chuan Shi, Serge Zolotukhin, Herbert Herzog, Amanda Sainsbury
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3387009?pdf=render

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http://europepmc.org/articles/PMC3387009?pdf=render

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