Ambulacrarian insulin-related peptides and their putative receptors suggest how insulin and similar peptides may have evolved from insulin-like growth factor
Background Some insulin/IGF-related peptides (irps) stimulate a receptor tyrosine kinase (RTK) that transfers the extracellular hormonal signal into an intracellular response. Other irps, such as relaxin, do not use an RTK, but a G-protein coupled receptor (GPCR). This is unusual since evolutionaril...
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| Format: | Article |
| Language: | English |
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PeerJ Inc.
2021-07-01
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| Series: | PeerJ |
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| Online Access: | https://peerj.com/articles/11799.pdf |