Teriflunomide – The common drug with underestimated oxygen - Dependent anticancer potential

Teriflunomide – The common drug with underestimated oxygen - Dependent anticancer potential

Leflunomide (LFN) is a well-known immunomodulatory and anti-inflammatory prodrug of teriflunomide (TFN). Due to pyrimidine synthesis inhibition TFN also exhibits potent anticancer effect. Because, there is the strict coupling between the pyrimidine synthesis and the mitochondrial respiratory chain,...

Full description

Bibliographic Details
Main Authors: Dagmara Otto-Ślusarczyk, Wojciech Graboń, Magdalena Mielczarek-Puta, Alicja Chrzanowska
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Biochemistry and Biophysics Reports
Subjects:
Tissue normoxia
Hypoxia
DHODH
Leflunomide
Teriflunomide
Colon cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580821002351

Internet

http://www.sciencedirect.com/science/article/pii/S2405580821002351

Similar Items