Operant sensation seeking requires metabotropic glutamate receptor 5 (mGluR5).

Pharmacological and genetic studies have suggested that the metabotropic glutamate receptor 5 (mGluR5) is critically involved in mediating the reinforcing effects of drugs of abuse, but not food. The purpose of this study was to use mGluR5 knockout (KO), heterozygous (Het), and wildtype (WT) mice to...

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Bibliographic Details
Main Authors: Christopher M Olsen, Daniel S Childs, Gregg D Stanwood, Danny G Winder
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-11-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2994905?pdf=render