Strong Clonal Relatedness between Serum and Gut IgA despite Different Plasma Cell Origins

Strong Clonal Relatedness between Serum and Gut IgA despite Different Plasma Cell Origins

Mucosal antigens induce generation of lamina propria plasma cells (PCs) that secrete dimeric immunoglobulin A (IgA) destined for transport across the epithelium. In addition, blood contains monomeric IgA. To study the relationship between mucosal and systemic antibody responses, we took advantage of...

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Bibliographic Details
Main Authors: Rasmus Iversen, Omri Snir, Maria Stensland, José E. Kroll, Øyvind Steinsbø, Ilma R. Korponay-Szabó, Knut E.A. Lundin, Gustavo A. de Souza, Ludvig M. Sollid
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Cell Reports
Subjects:
proteomics
antibodies
plasma cells
mucosal immune system
autoimmunity
celiac disease
mass spectrometry
next-generation sequencing
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717311439

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http://www.sciencedirect.com/science/article/pii/S2211124717311439

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