HMG-CoA reductase inhibition promotes neurological recovery, perilesional tissue remodeling and contralesional pyramidal tract plasticity after focal cerebral ischemia

HMG-CoA reductase inhibition promotes neurological recovery, perilesional tissue remodeling and contralesional pyramidal tract plasticity after focal cerebral ischemia

3-Hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors are widely used for secondary stroke prevention. Besides their lipid-lowering activity, pleiotropic effects on neuronal survival, angiogenesis and neurogenesis have been described. In view of these observations, we were interested...

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Bibliographic Details
Main Authors: Ertugrul eKilic, Raluca eReitmeir, Ulkan eKilic, Ahmet Burak Caglayan, Mustafa Caglar Beker, Taha eKelestemur, Muhsine Sinem Ethemoglu, Gurkan eOzturk, Dirk M. Hermann
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-12-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Neuronal Plasticity
tract tracing
middle cerebral artery occlusion
statin
neurological recovery
restorative therapy
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00422/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00422/full

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