Screening for Small Molecule Modulators of <i>Trypanosoma brucei</i> Hsp70 Chaperone Activity Based upon Alcyonarian Coral-Derived Natural Products

Screening for Small Molecule Modulators of <i>Trypanosoma brucei</i> Hsp70 Chaperone Activity Based upon Alcyonarian Coral-Derived Natural Products

The <i>Trypanosoma brucei</i> Hsp70/J-protein machinery plays an essential role in survival, differentiation, and pathogenesis of the protozoan parasite, and is an emerging target against African Trypanosomiasis. This study evaluated a set of small molecules, inspired by the malonganenon...

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Bibliographic Details
Main Authors: Sarah K. Andreassend, Stephen J. Bentley, Gregory L. Blatch, Aileen Boshoff, Robert A. Keyzers
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Marine Drugs
Subjects:
anti-parasitic
heat shock protein
malonganenone
sar
african trypanosomiasis
Online Access:https://www.mdpi.com/1660-3397/18/2/81

Internet

https://www.mdpi.com/1660-3397/18/2/81

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