Notch Signaling Pathway Is Activated in Motoneurons of Spinal Muscular Atrophy

Notch Signaling Pathway Is Activated in Motoneurons of Spinal Muscular Atrophy

Spinal muscular atrophy (SMA) is a neurodegenerative disease produced by low levels of Survival Motor Neuron (SMN) protein that affects alpha motoneurons in the spinal cord. Notch signaling is a cell-cell communication system well known as a master regulator of neural development, but also with impo...

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Bibliographic Details
Main Authors: Gabriel Olmos, Lucía Tabares, Jerònia Lladó, Rosa M. Soler, Laura Torres-Benito, Andrea Cardona-Rossinyol, Ana Garcera, Víctor Caraballo-Miralles
Format: Article
Language:English
Published: MDPI AG 2013-05-01
Series:International Journal of Molecular Sciences
Subjects:
SMA
Notch
NICD
Jagged1
Delta1
Neurogenin 3
astrocyte
motoneuron
Online Access:http://www.mdpi.com/1422-0067/14/6/11424

Internet

http://www.mdpi.com/1422-0067/14/6/11424

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