GM2/GD2 and GM3 gangliosides have no effect on cellular cholesterol pools or turnover in normal or NPC1 mice

GM2/GD2 and GM3 gangliosides have no effect on cellular cholesterol pools or turnover in normal or NPC1 mice

These studies investigated the role of gangliosides in governing the steady-state concentration and turnover of unesterified cholesterol in normal tissues and in those of mice carrying the NPC1 mutation. In animals lacking either GM2/GD2 or GM3 synthase, tissue cholesterol concentrations and synthes...

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Bibliographic Details
Main Authors: Hao Li, Stephen D. Turley, Benny Liu, Joyce J. Repa, John M. Dietschy
Format: Article
Language:English
Published: Elsevier 2008-08-01
Series:Journal of Lipid Research
Subjects:
Niemann-Pick type C disease
membrane cholesterol
glycosphingolipids
neurodegeneration
cholesterol synthesis
brain cholesterol
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520347003

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http://www.sciencedirect.com/science/article/pii/S0022227520347003

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