Malnutrition Decreases Antibody Secreting Cell Numbers Induced by an Oral Attenuated Human Rotavirus Vaccine in a Human Infant Fecal Microbiota Transplanted Gnotobiotic Pig Model

Malnutrition Decreases Antibody Secreting Cell Numbers Induced by an Oral Attenuated Human Rotavirus Vaccine in a Human Infant Fecal Microbiota Transplanted Gnotobiotic Pig Model

Human rotavirus (HRV) is a leading cause of morbidity and mortality in children, especially in developing countries. Malnutrition is prevalent in these countries, which may contribute to the decreased oral vaccine efficacy, posing a concern for global health. Neonatal gnotobiotic (Gn) pigs closely r...

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Bibliographic Details
Main Authors: Husheem Michael, Stephanie N. Langel, Ayako Miyazaki, Francine C. Paim, Juliet Chepngeno, Moyasar A. Alhamo, David D. Fischer, Vishal Srivastava, Dipak Kathayat, Loic Deblais, Gireesh Rajashekara, Linda J. Saif, Anastasia N. Vlasova
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Immunology
Subjects:
rotavirus
vaccine
malnutrition
adaptive immunity
B cells
human microbiota
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00196/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00196/full

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